A Review On Substitution Quinoline Derivatives and its Biological Activity

Abstract

Quinoline or 1-aza-naphtalene or benz[b]pyridine is nitrogen containing heterocyclic aromatic Compound. Quinoline ring having 2,4-disubstitution plays an important role in the search of new anti-cancer agents as these derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis. Quinoline and its fused heterocyclic derivatives tested with diverse pharmacological activity functional groups constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. The present review provides an in depth view of work done so far on quinolines and its biological activities covering anticancer, antimycobacterial, antimicrobial, anticonvulsant, anti-inflammatory and cardiovascular activities.