A Review on Substituted Thiadiazole and its Antimicrobial Activity

Abstract

Five-member heterocyclic compound show various type of biological activity among them 2,5-disubstituted 1,3,4-thiadiazole are associated with diverse biological activity probably virtue of –N=C-S grouping. Therapeutic importance of these rings prompted us to developed selective molecules in which substituted could be arrange in a pharmacophoric pattern to display higher pharmacological activity. Thiadiazole have occupied an important place in drug industry.1,3,4-thiadiazole have wide application in many field. Earliest uses were in the pharmaceutical area as an antibacterial with sulphonamide drugs. Some of other uses are antitumor, anti-inflammatory, pesticide, dyes, lubricant and reagent.