Synthesis Characterization and Antimicrobial Activity of Some Novel Oxadiazole Derivatives

Abstract

In the present study 1,3,4-Oxadiazole derivatives were synthesized and antimicrobial activities of different derivatives were checked with various microbial stains. Various intermediates were synthesized and characterized in between time-to-time by chromatographic and spectral methods. Substituted benzaldehyde and o-phenylenediamine were the starting material and finally formed of 1,3,4-oxadiazol-2-ylmethyl)-2-phenyl-1H- benzimidazole derivatives steps 1, dry acetone and ethyl chloro acetate react at room temperature and to of ethyl2phenyl1benzimidazole1yl) acetate 1,3,4-oxadiazole derivative have been synthesize from Schiff base of the corresponding hydrazine by using ethanol with reflex. finally treated with phosphorus chloride oxide to get the title compound. The structures of all the synthesized compound were established on the basic of elemental, chromatographic and spectral analysis. The synthesized compound was evaluated for their antimicrobial activity. The compound most active be against Escherichia coli and staphylococcus aureus.