Formulation of Novel Polyherbal Extract for Anti Diabetic Effect in Alloxan Induced Diabetic Rats

Abstract

In present study, some plants are selected for these study in which Azadirachta Indica (Neem), Catharanthus Roseus (Vinca), and Acacia Nilotica (Babhul). Albino rats were treated with prepared polyherbal extracts at doses of 300 mg/kg, 500 mg/kg and 800 mg/kg, did not extensively lower normal blood glucose level as compared to normal control animals that is polyherbal extracts did not possess hypoglycaemic activity. Alloxan at the dose of 150 mg/kg could significantly elevate blood glucose level in all groups of animals as compared to normal control animals. 21 days treated albino rats with polyherbal extracts at doses of 300 mg/kg; 500mg/kg and 800 mg/kg significantly lower normal blood glucose level as compared to diabetic control group but not when compare with blood glucose level of group treated with standard drug. The result was bringing into being to be dose dependent and did not possess hypoglycaemic but possess antidiabetic activity.