Formulation of Novel Polyherbal Extract for Anti Diabetic Effect in Alloxan Induced Diabetic Rats

Authors

  • Mahesh Kolhe Assistant Professor, Department of Pharmacology, DJP College of Pharmacy, Pathri, India
  • Amol Giri Assistant Professor, Department of Pharmaceutics, Samarth College of Pharmacy, Deulgaon Raja, India
  • Vishal Sakhare Assistant Professor, Department of Quality Assurance, DJP College of Pharmacy, Pathri, India
  • Ravi Pimple Assistant Professor, Department of Pharmaceutics, DJP College of Pharmacy, Pathri, India

Keywords:

Acacia Nilotica (Leaves), Azadirachta Indica (Leaves), Catharanthus Roseus (Leaves), Diabetes Mellitus (DM), Gastroparesis, HHNS (Hyperosmolar Hyperglycemic Nonketotic Syndrome), PAD (peripheral arterial disease)

Abstract

In present study, some plants are selected for these study in which Azadirachta Indica (Neem), Catharanthus Roseus (Vinca), and Acacia Nilotica (Babhul). Albino rats were treated with prepared polyherbal extracts at doses of 300 mg/kg, 500 mg/kg and 800 mg/kg, did not extensively lower normal blood glucose level as compared to normal control animals that is polyherbal extracts did not possess hypoglycaemic activity. Alloxan at the dose of 150 mg/kg could significantly elevate blood glucose level in all groups of animals as compared to normal control animals. 21 days treated albino rats with polyherbal extracts at doses of 300 mg/kg; 500mg/kg and 800 mg/kg significantly lower normal blood glucose level as compared to diabetic control group but not when compare with blood glucose level of group treated with standard drug. The result was bringing into being to be dose dependent and did not possess hypoglycaemic but possess antidiabetic activity.

Downloads

Download data is not yet available.

Downloads

Published

19-10-2020

How to Cite

[1]
M. Kolhe, A. Giri, V. Sakhare, and R. Pimple, “Formulation of Novel Polyherbal Extract for Anti Diabetic Effect in Alloxan Induced Diabetic Rats”, IJRESM, vol. 3, no. 10, pp. 82–89, Oct. 2020.

Issue

Section

Articles