Formulation and Evaluation of Fexofenadine HCL Oral Dispersable Tablets

Abstract

Fexofenadine chloride is an anti-histamine drug used in the treatment of hayfever and allergies symptoms. its oral absorption is 33% and having 14.4 hrs of half-life and belongs to BCS class II drug., a favourable formulation which can enhance solubility and dissolution rate of this model drug may help effectively in the treatment of bacterial infections. Efficiency and bioavailability of poorly soluble drug Fexofenadine HCL through solid dispersion technique using HP Beta cyclodextrine and beta cyclodextrine. the evaluation parameters and method of preparation of physical mixtures and solid dispertions of Fexofenadine HCL by solvent evaporation was explained. Charecterization in solid state was done by various analytical techniques such as FT-IR studies.