Formulation and Evaluation of Transdermal Patch Containing Naproxen

Abstract

Transdermal route is most popular route for deliver the specific amount of drug through the skin into the blood stream .an advantage of transdermal route of drug delivery avoid the first pass metabolism and controlled release of medication. The present study was aimed to formulate transdermal patch of NSAID, naproxen used to cure the pain, inflammation, by using solvent evaporation technique. Naproxen transdermal patches were prepared using different concentration of HPMC and methylcellulose. DMSO permeation enhancer, polyethylene glycol as a plasticizer and finally methanol: dichloromethane (2:1) ratio used as solvent altering the two polymeric concentrations. We can formulate different formulations by keeping drug constant dose (f1 to f7) and evaluate parameter to get optimizing good releasing formulation.