Investigation of In-Vitro Antioxidant and Ex-Vivo Anti Cataract Activity of Ethanolic Extract of Solanum Surattense Burm F (Indians Nightshade) Leaves

Abstract

Objective: To investigate the in-vitro anti-oxidant and ex-vivo anti-cataract activity of ethanolic extract of Solanum surattense (EESS) leaves on glucose induced cataract and hydrogen peroxide induced cataract using isolated goat lenses. Methods: Anti-oxidant activity done by using specific free radical scavenging methods like DPPH free radical, H₂O₂ free radical scavenging methods and the Anti-cataract activity done by using glucose induced cataract and hydrogen peroxide induced cataract using isolated goat lenses. Results: Results of the study conducted in the ethanolic extract of leaves of solanum surattense revealed the presence of numerous phytochemicals such as alkaloids, glycosides, saponins, tannins, flavonoids, proteins etc, which revealed that the plant contains several phytochemical constituents and hence possesses good anti-oxidant activity. From all the methods gave strong evidence regarding the anti-oxidant potential of this plant. Anti-cataract activity was also investigated using isolated goat lens and promising results were obtained which speak voluminously about its anti-cataract potential and support it well prescribed use. Conclusion: Results obtained with the study clearly supported the significant anti-oxidant potential and anti-cataract activity of this plant. Further, this plant demands great attention for the development of suitable novel dosage forms for the effective treatment of cataract.