Bactericidal Activity of Di-m-Toluidine Phosphate Having C-N-P Linkage

Abstract

Antibiotic resistance is rising to perilously high levels in all parts of the world. Due to the increasing development of drug resistance to antibacterial agents, demand for searching novel antibacterial agents is being screened. Di-m-toluidine phosphate has been synthesized by the reaction of m-toluidine, with phosphorylating agent POCl3 by known method and characterized by elemental and IR spectral analysis. Synthesized di phosphate ester has been screened for bactericidal activity against isolated bacteria. The isolation of bacteria and their characterization by different methods has been carried out. Different concentrations of phosphate esters in DMSO were applied to examine their antibacterial activity against coccus gram positive and gram negative bacteria by paper disc diffusion method. The study reveals that phosphate ester is highly effective against coccus gram negative bacteria as compared to gram positive bacteria.