Synthesis and Antimicrobial Screening of Some Substituted 1,3,4-Oxadiazole Derivatives

Abstract

The 1,3,4-oxadiazole derivatives are aromatic heterocycles with low lipophilicity, which are useful in medication development. By replacing at the 2- and 5-positions, the heterocycle's electrical and hydrogen bond-accepting properties can be altered, allowing it to be used as a carbonyl bioisotere. The 1,3,4-oxadiazole derivative [4-(5chloro-1,3,4-oxadiazole-2-yl) benzenamine is formed when para-aminobenzoic acid is combined with ethyl alcohol to make para-aminoethylbenzoate, which then combines with hydrazine to form para-aminoethylbenzoate]. The structure of freshly synthesized compounds was determined using the IR method. Furthermore, for antibacterial and antifungal activity against all of the selected microbial strains, these compounds were compared to ciprofloxacin and ketoconazole, which served as the gold standard.