An Overall Review on Preparation and Applications of Dendrimers

Abstract

Dendrimers are a new class of polymeric substances, which are highly branched, monodisperse, and artificial macromolecules dendrimers having a well-defined, shape, size, molecular weight and monodispersity. In1978, vogtle was first introduced chemistry of dendrimer. In 1980 Donald tomalia and coworkers discovered highly branched polymers called dendrimers dendrimers has a wide range of application in pharmaceutical field, as diagnostic substitute as blood substituent, as solubility enhancer now-a-days dendrimers are main nanoparticles which are applied to drug delivery systems. The review is focused on method of preparation and applications of dendrimers. Nano formulations are mainly based on dendrimers which enhances low solubility drugs, arrives to target tissues, drugs bioavailability and controlled release. Dendrimers are macromolecular structures , the drugs can be ensnare in the infra molecular cavity of the dendrimers and which are conjugated to their surface biological properties such as polyvalence, self-assembling, electrostatic interactions, chemical stability, low cytoxicity and solubility . These diverse characteristics make dendrimers a good choice in the medical field this review covers types and applications.