Animal and Mouse Models for Cystic Fibrosis

Authors

  • Arijeet Dedhe Student, D.Y. Patil School of Biotechnology and Bioinformatics, Mumbai, India
  • Fazlur Khan Student, D.Y. Patil School of Biotechnology and Bioinformatics, Mumbai, India
  • Arijit Ghosh Student, D.Y. Patil School of Biotechnology and Bioinformatics, Mumbai, India
  • Shreeraj Tumbde Student, D.Y. Patil School of Biotechnology and Bioinformatics, Mumbai, India

Keywords:

Cystic fibrosis, Mouse models, CFTR protein, Animal models, Genetically engineered mouse

Abstract

Cystic fibrosis mouse models are tools that enable us to study and understand the mechanisms and complexities of cystic fibrosis. Mouse models are better, and usually preferred when compared to other animal models, because of their high reproduction rate, low cost, and easy maintenance. A Mouse can be easily genetically manipulated by making it a transgenic or knockout mouse. However, as there are anatomic and immunological differences between mice and humans, these models have inherent limitations which need to be accounted for when analyzing the results obtained from experiments. This review focuses on the different CF mouse models which represent diverse phenotypes observed in humans with cystic fibrosis. This can potentially help researchers interpret the diverse functions of the CFTR protein.

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Published

07-12-2021

Issue

Section

Articles

How to Cite

[1]
A. Dedhe, F. Khan, A. Ghosh, and S. Tumbde, “Animal and Mouse Models for Cystic Fibrosis”, IJRESM, vol. 4, no. 12, pp. 5–9, Dec. 2021, Accessed: Dec. 01, 2024. [Online]. Available: https://journal.ijresm.com/index.php/ijresm/article/view/1573